Cellular OS
← Ingredient library
04Choline donor

Citicoline

CDP-choline

Choline and cytidine donor for phospholipid synthesis and acetylcholine availability.

Protocol status:Validated by JimEvidence stage:EmergingReview status:Review pendingSources:1 source verified
Primary module
Brain Performance
Protocol status
Validated by Jim
Evidence stage
Emerging
Protocol version
Personal Protocol v2.1
Last reviewed
Pending scientific review
04.01Doses

Personal, research and authoritative doses are always shown separately. They must never be combined into a single value.

Jim's personal dose
500 mg (baseline)
Up to 1,000 mg on high cognitive-demand days

Jim's personal protocol dose. Not a general dosage recommendation.

Doses in linked research
Research review pending

Doses used in referenced studies are extracted per source and may differ from personal use.

Authoritative recommendation
Not applicable / review pending

Shown only when a relevant authoritative reference (e.g. NIH ODS) publishes one and it has been verified against this record.

04.02Why it is here

Role in the operating system

Choline and cytidine donor for phospholipid synthesis and acetylcholine availability.

Intended outcome: Support attention and cognitive performance during demanding cognitive work.

Evidence remains bounded by the specific populations, formulations, doses and durations studied. Investigation is ongoing.

04.03Biological mechanism

Proposed mechanism

Research review pending

This section has not yet completed scientific review. No conclusion is currently published.

04.04Expected benefits

Expected benefits

Research review pending

This section has not yet completed scientific review. No conclusion is currently published.

04.05Safety and interactions

Safety, contraindications and interactions

Research review pending

This section has not yet completed scientific review. No conclusion is currently published.

04.06Biomarkers

Relevant biomarkers

Research review pending

This section has not yet completed scientific review. No conclusion is currently published.

04.07Decision history

Decision history

Research review pending

This section has not yet completed scientific review. No conclusion is currently published.

04.08Primary sources

Linked research

Primary studySource verified

Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

PMID 33978188· Verified 2026-07-15
Detailed extraction (authors, journal, year, population, dose, duration, results, limitations, funding, conflicts) is pending scientific review. Only the source identifier and title are currently confirmed. Open source.
04.085Pathway context

Citicoline within the wider pathway map. Measurement column stays honest — nothing is invented where scientific review is pending.

  • Citicoline
    500 mg (baseline)
    Brain Performance
    01
    System role · mechanism
    Choline and cytidine donor for phospholipid synthesis and acetylcholine availability.
    02
    Intended outcome
    Support attention and cognitive performance during demanding cognitive work.
    03
    Module
    Brain Performance · Module 01
    04
    Relevant measurement
    Relevant measurement mapping · research review pending
  • Creatine
    10 g
    Muscle, Protein & Physical Performance
    01
    System role · mechanism
    Phosphocreatine buffering for high-turnover ATP demand in muscle and brain.
    02
    Intended outcome
    Support strength, high-intensity capacity and possible cognitive resilience under load.
    03
    Module
    Muscle, Protein & Physical Performance · Module 03
    04
    Relevant measurement
    Relevant measurement mapping · research review pending
  • Lion's Mane
    900 mg
    Brain Performance
    01
    System role · mechanism
    Investigated for effects on neurotrophic factor signalling.
    02
    Intended outcome
    Investigated for cognitive support in healthy adults.
    03
    Module
    Brain Performance · Module 01
    04
    Relevant measurement
    Relevant measurement mapping · research review pending
  • L-Theanine
    200 mg
    Brain Performance
    01
    System role · mechanism
    Modulation of alpha-wave activity and perceived stress.
    02
    Intended outcome
    Support calm focus, often paired with caffeine or high cognitive load.
    03
    Module
    Brain Performance · Module 01
    04
    Relevant measurement
    Relevant measurement mapping · research review pending
04.09Related ingredients
Cellular energy substrate
Creatine
Fungal extract
Lion's Mane
Amino acid
L-Theanine
Essential fatty acids
Omega-3
Scientific disclaimer

The Cellular Performance Operating System documents an individual educational and personal performance framework. It is not medical advice, diagnosis or treatment. Personal protocol doses are not general recommendations. Supplement use, laboratory testing and medical decisions should be reviewed with an appropriately qualified healthcare professional.

Evidence may apply only to the specific populations, formulations, doses and durations studied.