Cellular OS
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04NAD+ precursor

NMN

Nicotinamide mononucleotide

Precursor investigated for NAD+ availability.

Protocol status:Validated by JimEvidence stage:EmergingReview status:Review pendingSources:1 source verified
Primary module
Cellular Energy & Longevity
Protocol status
Validated by Jim
Evidence stage
Emerging
Protocol version
Personal Protocol v2.1
Last reviewed
Pending scientific review
04.01Doses

Personal, research and authoritative doses are always shown separately. They must never be combined into a single value.

Jim's personal dose
800 mg

Jim's personal protocol dose. Not a general dosage recommendation.

Doses in linked research
Research review pending

Doses used in referenced studies are extracted per source and may differ from personal use.

Authoritative recommendation
Not applicable / review pending

Shown only when a relevant authoritative reference (e.g. NIH ODS) publishes one and it has been verified against this record.

04.02Why it is here

Role in the operating system

Precursor investigated for NAD+ availability.

Intended outcome: Investigated for effects related to NAD+ metabolism in adults.

Evidence remains bounded by the specific populations, formulations, doses and durations studied. Investigation is ongoing.

04.03Biological mechanism

Proposed mechanism

Research review pending

This section has not yet completed scientific review. No conclusion is currently published.

04.04Expected benefits

Expected benefits

Research review pending

This section has not yet completed scientific review. No conclusion is currently published.

04.05Safety and interactions

Safety, contraindications and interactions

Research review pending

This section has not yet completed scientific review. No conclusion is currently published.

04.06Biomarkers

Relevant biomarkers

Research review pending

This section has not yet completed scientific review. No conclusion is currently published.

04.07Decision history

Decision history

Research review pending

This section has not yet completed scientific review. No conclusion is currently published.

04.08Primary sources

Linked research

Primary studySource verified

The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial

PMID 36482258· Verified 2026-07-15
Detailed extraction (authors, journal, year, population, dose, duration, results, limitations, funding, conflicts) is pending scientific review. Only the source identifier and title are currently confirmed. Open source.
04.085Pathway context

NMN within the wider pathway map. Measurement column stays honest — nothing is invented where scientific review is pending.

  • NMN
    800 mg
    Cellular Energy & Longevity
    01
    System role · mechanism
    Precursor investigated for NAD+ availability.
    02
    Intended outcome
    Investigated for effects related to NAD+ metabolism in adults.
    03
    Module
    Cellular Energy & Longevity · Module 02
    04
    Relevant measurement
    Relevant measurement mapping · research review pending
  • Creatine
    10 g
    Muscle, Protein & Physical Performance
    01
    System role · mechanism
    Phosphocreatine buffering for high-turnover ATP demand in muscle and brain.
    02
    Intended outcome
    Support strength, high-intensity capacity and possible cognitive resilience under load.
    03
    Module
    Muscle, Protein & Physical Performance · Module 03
    04
    Relevant measurement
    Relevant measurement mapping · research review pending
  • Omega-3
    Fish oil 4.8 g · EPA 1,728 mg + DHA 1,152 mg (2,880 mg EPA+DHA)
    Brain Performance
    01
    System role · mechanism
    Structural component of cell membranes; substrate for resolving mediators.
    02
    Intended outcome
    Support membrane composition and inflammation resolution.
    03
    Module
    Brain Performance · Module 01
    04
    Relevant measurement
    Relevant measurement mapping · research review pending
  • Calcium alpha-ketoglutarate
    2 g
    Cellular Energy & Longevity
    01
    System role · mechanism
    Alpha-ketoglutarate is a Krebs-cycle intermediate investigated in aging research.
    02
    Intended outcome
    Investigated in aging and metabolic pathway research.
    03
    Module
    Cellular Energy & Longevity · Module 02
    04
    Relevant measurement
    Relevant measurement mapping · research review pending
04.09Related ingredients
Cellular energy substrate
Creatine
Essential fatty acids
Omega-3
TCA intermediate
Calcium alpha-ketoglutarate
Mitophagy activator
Urolithin A
Scientific disclaimer

The Cellular Performance Operating System documents an individual educational and personal performance framework. It is not medical advice, diagnosis or treatment. Personal protocol doses are not general recommendations. Supplement use, laboratory testing and medical decisions should be reviewed with an appropriately qualified healthcare professional.

Evidence may apply only to the specific populations, formulations, doses and durations studied.